You might alo consider to travel by train or bus.
NS Railway station Den Bosch Centraal, knows many direct connection to and from Utrecht, Eindhoven, Tilburg, Breda, Amsterdam, Schiphol Airport and more. Do you choose to travel by train it's only a 5 minute walk to the City Centre Hotel. You might also choose to take one of the many taxi's available at het Railway station, to bring you with your luggage to the City Centre Hotel.
Do you travel by bus you might exit at the Centraal Station and take a walk form there, or take a connected bus to the city centre. The closest busstop is; Parade, and then it's a 1 minute walk.